PDRN is a naturally occurring building block in DNA that helps to repair damaged skin cells and stimulate collagen production. PDRN is derived from a controlled purification and sterilization process of Oncorhynchus mykiss (Salmon Trout) or Oncorhynchus keta (Chum Salmon) sperm DNA. The procedure guarantees the absence of active protein and peptides that may cause immune reactions.
PDRN molecules are able to effectively stimulate the metabolic activity in cells and promote the process of skin repair re-epithelialization. As a result, Polynucleotides are effective in the treatment of stretch marks, acne scars, fine lines and wrinkles.
PDRN is 40% more effective in fibroblast stimulation than Hyaluronic Acid. This results in a 60% increase in collagen synthesis. It tones and hydrates the skin, improving skin firmness and elasticity and minimizing pores.
Additionally, PDRN also protects cells from UV-induced DNA damage. Exposure of human dermal fibroblasts to ultraviolet B radiation causes the accumulation of dangerous photoproducts. PDRN addition to the cell culture results in p53 protein activation and in enhancing DNA repair.
PDRN's most relevant mechanism of action is the engagement of adenosine A2A. A great number of pathological and aging processes are associated with chronic inflammation. Polynucleotides stimulate the A2A adenosine receptors. This elicits a wide range of responses that can be classified as an anti-inflammatory.
Reduces fine lines and wrinkles
Whitens and brightens the skin
Improves the skin tone and elasticity
Combats severe dehydration
Strengths skin barrier
Reduces the appearance of stretch marks and acne scars